I've got a microsoft sidewinder mouse x5, and a sidewinder keyboard x6 with a detatchable numpad that can swap to the left and become a macropad. If you're looking for a comfortable experience with remappable keys, this is highly workable. A bit pricey, but it's fun to pimp your gear a bit.
On the opposite side, I've also used a ps3 bluetooth keypad to map all my spells and such, and it's also great for raids and quick responsive controls. It takes a little getting used to, but when you've set it all up through your key bindings, it's super quick and effective.